Cral-trio lipid binding domain

Author: qmwb

August undefined, 2024

WebAug 1, 2008 · • Proteins containing the lipid-binding Sec14 domain, also referred to as the CRAL-TRIO domain, ar e found throughout eukaryotic organisms ranging from yeast to humans. WebApr 3, 2024 · The bipartite sequence motif is composed of CRAL_TRIO_C and N domains, with CRAL_TRIO_C forming the lipid-binding pocket. ( B ) Subcellular localization of CPSFL1-YFP.

MOSPD2 is an endoplasmic reticulum–lipid droplet tether …

WebJan 31, 2024 · The GOLD domain has an average of 90-150 amino acids and is usually combined with sterol-, fatty- or lipid-binding domains ... The SEC14L structure is mainly composed of the so-called CRAL-TRIO domain, a globular domain with the function of binding, transferring, ... WebFeb 15, 2024 · CRAL-TRIO lipid binding domain superfamily; KEGG Genes - Molecular building blocks of life in the genomic space. Dmel_CG30339; MARRVEL_MODEL - MARRVEL (model organism gene) 246549; modMine - A data warehouse for the modENCODE project. FBgn0050339; Linkouts. BioGRID ... complete care at willow creek

ZFIN Gene: nf1b

WebMay 15, 2010 · CRAL/TRIO domains form hydrophobic binding pockets that bind small hydrophobic ligands (Bateman et al., 2000, Sha et al., 1998, ... Finally, TAP-1 may have lipid exchange activity as proposed for other CRAL/TRIO domain proteins (Phillips et al., 1999). In this case TAP-1 may regulate the lipid environment at the cell membrane, … WebCRAL-TRIO domain-containing protein C3H8.02: BLAST Add. Sequence: Modified residue: 40: Phosphoserine 1 publication. Sequence: S: Modified residue: 43: ... 3.40.525.10 CRAL-TRIO lipid binding domain 1 hit; InterPro. View protein in InterPro; IPR001251 CRAL-TRIO_dom; IPR036865 CRAL-TRIO_dom_sf; IPR011074 CRAL/TRIO_N_dom; … WebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. CRALB proptein carries 11-cis-retinol or 11-cis-retinaldehyde. It is a carrier that modulates interaction of retinoids with visual cycle enzymes. complete care burlington woods address

CPSFL1 encodes a chloroplast-targeted CRAL-TRIO domain …

FlyBase Gene Report: Dmel\CG30339

WebAug 23, 2024 · The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. [3] Structure. The Sec14 protein was the first CRAL-TRIO domain for which the structure was determined. [4] The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and … WebIt engages lipid droplets via its CRAL-TRIO domain, which specifically recognizes packing defects and negatively charged phospholipids . This module is also referred to as the SEC14 domain, and is known to bind PI lipids [ 124 , 125 ]. ebury street pimlicoWebThe bipartite CRAL_TRIO motif is composed of a large lobe encoding a hydrophobic lipid-binding pocket (CRAL_TRIO_C) that is closed off by a smaller N-terminal lobe (CRAL_TRIO_N) . To analyze the lipid-binding activity of CPSFL1, we used recombinant affinity-purified Sec14 proteins and performed protein−lipid blot overlay assays (Fig. 5A, … ebury uae

"http://pfam-legacy.xfam.org/family/CRAL_TRIO_2 " - Cral-trio lipid binding domain

Cral-trio lipid binding domain

Structure and function of the enigmatic Sec14 domain-containing ...

WebSpecific lipid-binding protein domains, such as PH, FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions between proteins and specific phospholipids. Here we review the published literature, plus some of our most recent unpublished findings, regarding the biology of the SEC14 domain, also known as CRAL_TRIO domain.

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WebThe Sec14 domain is depicted in yellow with N-terminal CRAL-TRIO domain as an oval structure. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] from ... WebCRAL-TRIO lipid binding domain which includes the vitamin E binding protein TTP (SMART-SM00516; PFAM-PF00650). The defining protein of this family is the yeast phospholipid transfer protein Sec14, containing a phospholipid binding cavity with a floor made of four parallel and two antiparallel beta-strands. Several α-helices cover the β …

WebMay 15, 2010 · The activation of the protein kinase Raf at the cell membrane is a critical step in cell signaling during development, but the mechanisms that regulate Raf activity remain incompletely defined. We previously demonstrated that the C. elegans cgr-1 gene encodes a CRAL/TRIO domain-containing protein that is a critical modulator of Ras … WebCRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily; UniProtKB:A8DZD4. InterPro 361: Transcripts . Genome Browsers. UCSC NCBI Ensembl ZFIN. Type Name Length (nt) Analysis ; mRNA: bnipl-201 Ensembl. 1400 nt: Select Tool ZFIN BLAST NCBI BLAST Ensembl ...

WebJul 1, 2015 · The CRAL_TRIO domain is an N-terminal ligand binding region within a larger protein domain (SEC14) that takes its name from common sequence elements in cellular retinaldehyde binding protein (CRALBP) and the signaling domain of the TRIO guanine exchange factor (Panagabko et al., 2003). ... The SEC14 domain contains a … WebApr 21, 2024 · Important regulators of PI phosphorylation and distribution are proteins harboring a CRAL_TRIO (cellular retinaldehyde binding-triple response) domain, for which yeast Sec14 is the prototype (2, 3). Sec14-like proteins bind PI in a hydrophobic cavity in the CRAL_TRIO domain. In that cavity, another hydrophobic ligand can be bound alternatively.

WebCRAL-TRIO lipid binding domain superfamily CRAL/TRIO, N-terminal domain CRAL/TRIO, N-terminal domain superfamily; UniProtKB:Q7SXG2. InterPro 118: UniProtKB:A0A0R4ITM7. InterPro 118: UniProtKB:B0S5J5. InterPro 285: Transcripts ...

WebCRAL-TRIO lipid binding domain superfamily PH-like domain superfamily Ras GTPase-activating domain Ras GTPase-activating protein Ras GTPase-activating protein, conserved site Rho GTPase activation protein; UniProtKB:E7FFY1. InterPro 2759: Transcripts Genome Browsers ... ebury street victoriaWebCRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily; UniProtKB:F6NPA8. InterPro 334: UniProtKB:A5WV31. InterPro 367: Transcripts . Genome Browsers. UCSC NCBI Ensembl ZFIN. Type Name Length (nt) Analysis ; … complete care community healthWebtriob. Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Human ortholog (s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and ... ebury valuationWebNov 1, 2024 · CRAL_TRIO family proteins are cytosolic and contain the SEC14 carboxy-terminal domain [7,9]. The CRAL_TRIO subgroup derives its name from the cellular retinaldehyde-binding protein (CRALBP) and the TRIO guanine exchange factor [11]. SEC14 was originally shown to be a cytosolic factor that promotes protein export from … complete care centers for imaging lake maryWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 ebury watfordWebThe CRAL-TRIO domain is a structurally conserved element of about 170 amino acids, which constitute a hydrophobic lipid binding pocket. The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and ... completecare community pharmacyWebSuperfamily assignments for Oryza sativa ssp. Indica . Summary assignment statistics followed by sortable table of detailed assignments with number of domains, proteins and families assigned for each superfamily. ebury way closure