Phospho-creb
WebTime-dependent induction of CREB phosphorylation in the hippocampus by the endogenous cannabinoid Masako Isokawa Department of Biological Sciences, The University of Texas at Brownsville, Brownsville TX 78520 Abstract The involvement of the endogenous cannabinoid system has been implicated in the rewarding actions of several drugs of abuse. CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
Phospho-creb
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WebMar 29, 2024 · The CREB binding domain, referred to as KIX, is α helical and binds to an unstructured kinase-inducible domain in CREB following phosphorylation of CREB at Ser-133. Phospho-Ser-133 forms direct contacts with residues in KIX, and these contacts are further stabilized by hydrophobic residues in the kinase-inducible domain which flank … WebUpon phosphorylation, CREB forms a functionally active dimer that binds the cis-acting CRE element within the promoters of target genes.220,221 Immediate-early genes, such as c-fos, Bcl-2, the IAPs, nNOS, and BDNF are important to neuronal survival and are gene targets of CREB. 221 Findings by Hardingham et al. 138 indicate that synaptic and …
WebMar 24, 2024 · p-CREB-1 Antibody (10E9) is an IgG1 κ mouse monoclonal p-CREB-1 antibody (also designated p-CREB-1 antibody or CREB antibody) suitable for the detection of Ser 133 phosphorylated CREB-1 and Ser 63 phosphorylated ATF-1 of mouse, rat and human origin by WB and IP. p-CREB-1 Antibody (10E9) is available as the non-conjugated anti-p … WebThe PathScan ® Phospho-CREB (Ser133) Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous levels of CREB when phosphorylated at Ser133. A CREB rabbit antibody has been coated onto the microwells.
WebProduct name Anti-CREB (phospho S129 + S133) antibody See all CREB primary antibodies Description Rabbit polyclonal to CREB (phospho S129 + S133) Host species Rabbit Tested applications Suitable for: ICC/IF, WB more details Species reactivity Reacts with: Mouse, Human Immunogen Synthetic peptide corresponding to Human CREB (phospho S129 + … WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity …
WebApr 11, 2024 · The classical PKC/ERK/CREB signaling pathway is involved in the synthesis of pituitary TSH . To evaluate whether the PKC/ERK/CREB signaling pathway mediates the regulation of TSH with CK1α, we analyzed the phosphorylation levels of PKC, ERK, and CREB in the mouse pituitary gland after treatment with 1 mg/mL D4476 or 5 mg/mL pyrvinium.
WebPhospho-CREB (Ser133) Antibody (44-298G) in ICC/IF Immunofluorescent analysis of Phospho-CREB pSer133 Antibody was done on 70% confluent log phase A549 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. small scale study nyt crosswordWebKnockdown of CREB (cAMP response element-binding protein) promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the … small scale study for short crossword clueWebCREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. [2] CREB was first described in 1987 as a cAMP -responsive transcription factor regulating the somatostatin gene. [3] small scale stock investmentsWebThis ChIPAb+ Phospho-CREB (Ser133) -ChIP Validated Antibody & Primer Set (Antibody ChIP) conveniently includes the antibody & the specific control PCR primers. MSDS … small scale study for short nytWebUse Anti-phospho-CREB (Ser133) Antibody (rabbit polyclonal antibody) is highly published and validated in EMSA, IHC,IHC(P), IP, WB to detect phospho-CREB (Ser133) also known … highrexfixWebPhosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in ... small scale sugar factory costWebMonoclonal antibody labeled with the LANCE® Eu-W1024-ITC chelate. This antibody recognizes specifically phosphorylated Ser133 in the cAMP response element binding (CREB) protein. CREB (Ser 133) can be phosphorylated by a variety of kinases including MSK1, PKA and PKC isoforms. small scale synonyms list